Lab of Cancer Biology
Publications (After 2021)
Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL. Nat Commun. 2024
Special Issue: Resistance to Targeted Therapies in Human Cancer. Lee TW, Choi HJ, Lee KM, Lee JY. Biomedicines. 2023
CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer.Son S, Kim H, Lim H, Lee JH, Lee KM, Shin I.Cell Death Dis. 2023
Brain type of creatine kinase induces doxorubicin resistance via TGF-β signaling in MDA-MB-231 breast cancer cells.Son S, Yoo SA, Nam K, Oh S, Lee KM, Yi JY, Shin I.Anim Cells Syst (Seoul). 2022
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim G, Sudhan DR, Mendiratta S, González Ericsson PI, Balko JM, Lee J, Barnes S, Malladi VS, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu YX, Hanker AB, Arteaga CL.Cancer Immunol Res. 2022
Immune Checkpoint Blockades in Triple-Negative Breast Cancer: Current State and Molecular Mechanisms of Resistance.Kim H, Choi JM, Lee KM.Biomedicines. 2022
ECM1 is associated with endocrine resistance in ER+ breast cancers.Lee TW, Lee KM.Anim Cells Syst (Seoul). 2022
Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL.Clin Cancer Res. 2021
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis,
and HER2 inhibitor sensitivity.Hanker AB, Brown BP, Meiler J, Marín A, Jayanthan HS, Ye D, Lin CC, Akamatsu H, Lee KM, Chatterjee S, Sudhan DR, Servetto A, Brewer MR, Koch JP, Sheehan JH, He J, Lalani AS, Arteaga CL.Cancer Cell. 2021
Publications (Before 2021)
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.Lee KM, Guerrero-Zotano AL, Servetto A, Sudhan DR, Lin CC, Formisano L, Jansen VM, González-Ericsson P, Sanders ME, Stricker TP, Raj G, Dean KM, Fiolka R, Cantley LC, Hanker AB, Arteaga CL.Nat Commun. 2020
A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics.Sapoznik E, Chang BJ, Huh J, Ju RJ, Azarova EV, Pohlkamp T, Welf ES, Broadbent D, Carisey AF, Stehbens SJ, Lee KM, Marín A, Hanker AB, Schmidt JC, Arteaga CL, Yang B, Kobayashi Y, Tata PR, Kruithoff R, Doubrovinski K, Shepherd DP, Millett-Sikking A, York AG, Dean KM, Fiolka RP.Elife. 2020
Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers.Sudhan DR, Guerrero-Zotano A, Won H, Ericsson PG, Servetto A, Huerta-Rosario M, Ye D, Lee KM, Formisano L, Guo Y, Liu Q, Kinch LN, Brewer MR, Dugger T, Koch J, Wick MJ, Cutler RE Jr, Lalani AS, Bryce R, Auerbach A, Hanker AB, Arteaga CL.Cancer Cell. 2020
Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors.Patel HK, Tao N, Lee KM, Huerta M, Arlt H, Mullarkey T, Troy S, Arteaga CL, Bihani T.Breast Cancer Res. 2019
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW.J Med Chem. 2019
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.Formisano L, Lu Y, Servetto A, Hanker AB, Jansen VM, Bauer JA, Sudhan DR, Guerrero-Zotano AL, Croessmann S, Guo Y, Ericsson PG, Lee KM, Nixon MJ, Schwarz LJ, Sanders ME, Dugger TC, Cruz MR, Behdad A, Cristofanilli M, Bardia A, O'Shaughnessy J, Nagy RJ, Lanman RB, Solovieff N, He W, Miller M, Su F, Shyr Y, Mayer IA, Balko JM, Arteaga CL.Nat Commun. 2019
ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors.Guerrero-Zotano AL, Stricker TP, Formisano L, Hutchinson KE, Stover DG, Lee KM, Schwarz LJ, Giltnane JM, Estrada MV, Jansen VM, Servetto A, Gavilá J, Perez-Fidalgo JA, Lluch A, Llombart-Cussac A, Bayar MA, Michiels S, André F, Arnedos M, Guillem V, Ruiz-Simon A, Arteaga CL.Clin Cancer Res. 2018
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL.Clin Cancer Res. 2018
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL.Cell Metab. 2017
Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.Jansen VM, Bhola NE, Bauer JA, Formisano L, Lee KM, Hutchinson KE, Witkiewicz AK, Moore PD, Estrada MV, Sánchez V, Ericsson PG, Sanders ME, Pohlmann PR, Pishvaian MJ, Riddle DA, Dugger TC, Wei W, Knudsen ES, Arteaga CL.Cancer Res. 2017
CD44 regulates cell proliferation, migration, and invasion via modulation of c-Src transcription in human breast cancer cells.Nam K, Oh S, Lee KM, Yoo SA, Shin I.Cell Signal. 2015
EGFR negates the proliferative effect of oncogenic HER2 in MDA-MB-231 cells.Oh S, Ju JH, Yang W, Lee KM, Nam K, Shin I.Arch Biochem Biophys. 2015
Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes.Ju JH, Oh S, Lee KM, Yang W, Nam KS, Moon HG, Noh DY, Kim CG, Park G, Park JB, Lee T, Arteaga CL, Shin I.Cell Death Differ. 2015
ECM1 regulates tumor metastasis and CSC-like property through stabilization of β-catenin.Lee KM, Nam K, Oh S, Lim J, Kim RK, Shim D, Choi JH, Lee SJ, Yu JH, Lee JW, Ahn SH, Shin I.Oncogene. 2015
ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2.Lee KM, Nam K, Oh S, Lim J, Lee T, Shin I.Cell Signal. 2015
Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling.Lee KM, Nam K, Oh S, Lim J, Kim YP, Lee JW, Yu JH, Ahn SH, Kim SB, Noh DY, Lee T, Shin I.Breast Cancer Res. 2014
CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK.Lim J, Lee KM, Shim J, Shin I.Arch Biochem Biophys. 2014
S100A4 negatively regulates β-catenin by inducing the Egr-1-PTEN-Akt-GSK3β degradation pathway.Yang W, Nam K, Ju JH, Lee KM, Oh S, Shin I.Cell Signal. 2014
Regulation of cell proliferation and migration by keratin19-induced nuclear import of early growth response-1 in breast cancer cells.Ju JH, Yang W, Lee KM, Oh S, Nam K, Shim S, Shin SY, Gye MC, Chu IS, Shin I.Clin Cancer Res. 2013
HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage.Ju JH, Yang W, Oh S, Nam K, Lee KM, Noh DY, Shin I.Biochem J. 2013
Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.Yang W, Ju JH, Lee KM, Nam K, Oh S, Shin I.Exp Cell Res. 2013
CD24 regulates cell proliferation and transforming growth factor β-induced epithelial to mesenchymal transition through modulation of integrin β1 stability.Lee KM, Ju JH, Jang K, Yang W, Yi JY, Noh DY, Shin I.Cell Signal. 2012
CD24 enhances DNA damage-induced apoptosis by modulating NF-κB signaling in CD44-expressing breast cancer cells. Ju JH, Jang K, Lee KM, Kim M, Kim J, Yi JY, Noh DY, Shin I.Carcinogenesis. 2011
Induction of apoptotic cell death by Pharbitis nil extract in HER2-overexpressing MCF-7 cells. Ju JH, Jeon MJ, Yang W, Lee KM, Seo HS, Shin I.J Ethnopharmacol. 2011
Akt isoform-specific inhibition of MDA-MB-231 cell proliferation. Yang W, Ju JH, Lee KM, Shin I.Cell Signal. 2011
Effects of endocrine disruptors on Bombina orientalis P450 aromatase activity. Lee KM, Yang W, Rhee JS, Hwang DS, Park CJ, Gye MC, Lee JS, Shin I.Zoolog Sci. 2010
Protein expression profiling of primary mammary epithelial cells derived from MMTV-neu mice revealed that HER2/NEU-driven changes in protein expression are functionally clustered. Park S, Lee KM, Ju JH, Kim J, Noh DY, Lee T, Shin I.IUBMB Life. 2010